Author

Yu-Ching Su

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Open access Oct 2026

The CLEC7A Y238∗ variant and susceptibility to pneumonia: a prospective population-based cohort study and mechanistic investigation.

BACKGROUND DECTIN-1, a C-type lectin receptor encoded by CLEC7A, mediates antifungal immunity, but its antibacterial role remains unclear. We investigated, using human genetic and animal studies, whether the common loss-of-function CLEC7A Y238∗ variant (rs16910526) influences susceptibility to bacterial respiratory inf...

Oskar Thofte, Valdemar Öhnström, Linda Yamba Yamba et al. · EBioMedicine · 0 citations

Open access Aug 2026

Transcriptional Regulator FabR Is Associated with the Virulence of Non-typeable Haemophilus influenzae in Host-Pathogen Interactions.

Deletion of fabR reduced host cell adherence, increased serum sensitivity, enhanced IgG deposition, and decreased vitronectin binding compared with the wild-type strain, and ΔfabR mutants from multiple NTHi strains showed increased metabolic activity, indicating a conserved role for FabR in metabolic regulation.

Martina Janoušková, Yu-Ching Su, Sandra Jonsson et al. · Journal of Infectious Diseas... · 0 citations