Yu-Chuan Tsai

Deciphering the modular structure of phage depolymerase: a dual-action strategy for biofilm degradation and targeted Pseudomonas aeruginosa binding

ABSTRACT Pseudomonas aeruginosa is a critical ESKAPE pathogen that can form strong biofilms, which protect it from antibiotics and the host’s immune system. Enzymes from bacteriophages, called depolymerases, are often found in tail fiber proteins and provide a useful way to break down these biofilms. In this work, we s...