Open access
Aug 2026
Hypoxia drives ferroptosis resistance and immunosuppression in hepatocellular carcinoma by inducing UBASH3B-mediated glutamine metabolism reprogramming and CXCL8 expression
A novel interaction between hypoxia, glutamine metabolic reprogramming, and immune suppression in HCC progression is uncovered, positioning UBASH3B as a promising therapeutic target for overcoming hypoxia-induced treatment resistance.
Guo-Qiang Pan, Shaokai Zhang, Xi Wang et al.
· Redox Biology · 0 citations