Yu-Dan Wang

Keratinocyte-derived CHI3L2 reprograms phospholipid metabolism to promote skin inflammation in psoriasis.

Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferative keratinocytes and a dysregulated cytokine milieu, perpetuating a self-reinforcing inflammatory cycle. Despite the key involvement of keratinocytes in this pathogenic loop, the molecular pathogenesis remains incompletely understood. He...