Yu Deng

Modular Whole-Cell Transaminase Cascades for Bioamination of Biomass-Derived Aldehydes through Amino-Donor Regeneration and Pyruvate Removal

The biocatalytic conversion of lignocellulose-derived aldehydes into value-added aromatic and heteroaromatic amines is often restricted by the reversibility of transamination, inefficient amine-donor utilization, pyruvate accumulation, and insufficient intracellular cofactor regeneration. In this study, three modular...

[Metabolic engineering of Yarrowia lipolytica for astaxanthin production].

Valorization of Food Waste and Marine Biomass into 5-(Hydroxymethyl)furfurylamine through the Sustainable Chemobiocatalytic Strategy

A single-vessel two-step chemobiocatalytic strategy was developed for conversion of d-fructose, bread crumbs, and marine biomass (purple laver) into value-added furanic chemicals. A ternary deep eutectic solvent (DES), Be/Gly/MaA, efficiently catalyzed 5-hydroxymethylfurfural (5-HMF) production from d-fructose, bread...

High-throughput screening coupled with laboratory adaptive evolution to enhance acid-tolerance and succinic acid production of Actinobacillus succinogenes.

By enabling efficient succinic acid production at low pH, the evolved A. succinogenes strains developed herein provide a feasible approach to lowering process costs and carbon emissions, accelerating the industrial adoption of bio-based succinic acid for biodegradable plastic production.

Metabolic engineering strategies for astaxanthin biosynthesis in non-native microbial cell factories.

Astaxanthin, a C40 carotenoid with exceptional antioxidant, anti-inflammatory, and anticancer physiological activities, has experienced surging market demand across cosmeceutical, food, and pharmaceutical industries. Traditional astaxanthin production methods have critical limitations, including high costs, significant...

Deep learning-driven de novo design of ribosome binding sites in Paracoccus denitrificans

This work establishes the first deep learning-enabled RBS design platform for P. denitrificans, offering a robust tool for precise translational regulation and advancing synthetic biology applications in environmental biotechnology.