Review
Open access
Sep 2026
CD97/ADGRE5 in Cancer: Structural Activation, Context-Dependent Signaling, and Therapeutic Targeting
Highlights What are the main findings? CD97 is involved in tumor stemness, invasion, metastasis, and cell survival through adhesion-related signaling, mechanosensing, and downstream pathway activation. CD97-targeted chimeric antigen receptor (CAR) therapies have shown antitumor activity in animal models, whereas CD97-t...
Yu-Hong Lei, Yuan Zhang, Yu-Feng Wang et al.
· Cells · 0 citations