TGM2 Activates the ERK Signaling Pathway to Disrupt Intestinal Barrier Function and Aggravate Colitis.
BACKGROUND PANoptosis-related transcriptional programs may contribute to pediatric ulcerative colitis (UC), but the genes most consistently associated with disease activity and epithelial injury remain uncertain. METHODS Public transcriptomic cohorts were integrated with machine-learning feature selection, treatment-...