Author

Yu-Feng Yuan

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Jul 2026

Towards Precision Therapy in Hepatocellular Carcinoma: A Clinical-Reasoning LLM for Risk Stratification and Treatment Guidance

HCC-STAR (Hepatocellular Carcinoma Staging, Treatment and pRognosis), a clinically aligned large language model that reads routine EMR narratives and jointly outputs risk score-based staging, ranked guideline-consistent treatments with evidence-based rationales, and individualized survival estimates, is presented.

Peng Cui, Ji-Tao Wang, Siyan Xue et al. · arXiv.org · 0 citations

Open access Jul 2026

PDIA6 exacerbates hepatocellular carcinoma via enhancing proteasome-dependent degradation of AKAP12.

This study experimentally validated that PDIA6 promotes the proliferation and metastasis of HCC cells and uncovered the HCC-promoting mechanism of the PDIA6-AKAP12-Wnt signaling axis and highlights its great potential for the development of therapeutic targets in HCC.

Rucheng Yao, Yuhan Yin, Xiaosong Li et al. · Cellular Oncology · 0 citations