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Author

Yuguang Mu

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#graph neural networks Open access Oct 2026

Filling the Missing Puzzle: Integrating Interaction and Evolutionary Information to Enhance Protein Fitness Prediction in Inverse Folding

Protein inverse folding, which infers compatible amino acid sequences from a given backbone structure, is central to rational protein design. Current methods rely largely on sequence recovery rate as the evaluation metric, emphasizing structural compatibility but seldom addressing function. Yet functional activity depe...

Zhi-Hao Wang, Zhong-Yang Zhang, Yan-Mei Yang et al. · 0 citations
Open access Sep 2026

Structure of the MurA-LpxC enzyme complex in modulating peptidoglycan and lipopolysaccharide biosynthesis.

Cryo-electron microscopy (cryo-EM) structures of the Pseudomonas aeruginosa MurA-LpxC complex in the absence and presence of the LpxC inhibitor CHIR-090 are determined, providing molecular insights into complex formation.

Joshua Yi Yeo, Xin-Fu Yan, Zhu Qiao et al. · 0 citations

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