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Author

Yuhan Dai

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Open access Sep 2026

Structural and Mechanistic Basis of Dual Substrate Promiscuity in the Acyltransferase AntB Enables Late-Stage Diversification of Natural Products.

Biocatalytic regioselective acylation is a powerful strategy for diversifying natural products and optimizing their pharmacological properties. Compared with plant acyltransferases (ATs), bacterial tailoring ATs remain poorly understood. AntB from the antimycin pathway was previously reported to possess acyl-donor prom...

Meng-Meng Zheng, Yu-Han Dai, Xiang-Yu Li et al. · 0 citations
Aug 2026

Iterative Enoyl Reduction by a FabV-Family Enzyme Expands the Chemical Landscape of Discrete Polyketide Synthases.

PbrC16, a FabV-family ER from a manumycin-type biosynthetic gene cluster (BGC) in Peterkaempfera bronchialis is characterized and reveals the molecular basis for its exceptional substrate promiscuity and versatile acyl carrier protein (ACP) recognition.

Yan Gao, Kai Jiang, Yu-Han Dai et al. · 0 citations

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