Review
Open access
Sep 2026
PSMD14 as a translational target in cancer and beyond: from deubiquitination mechanisms to drug resistance and precision therapy
The deubiquitinase PSMD14 (also known as RPN11 or POH1), a critical component of the JAB1/MPN/Mov34 metalloenzyme family, has emerged as a pivotal regulator of protein homeostasis through its deubiquitinating activity. While preclinical studies have extensively characterized PSMD14-mediated stabilization of oncogenic s...
Hong-Rui Liu, Liang Ma, Yi-Xuan Wang et al.
· Cancer Drug Resistance · 0 citations