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Author

Yu Hu

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2 papers indexed here

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Open access Sep 2026

Kidney fibrosis is mediated by GARP-restricted TGF-β activation in fibroblasts.

TGF-β is a central driver of kidney fibrosis, a common pathological hallmark of chronic kidney disease (CKD). Initiation of TGF-β signaling requires not only its synthesis but also the conversion of latent TGF-β to its bioactive form. However, the mechanisms governing TGF-β activation in the kidney and their contributi...

Yin-Tong Chen, Wei-Wei Xu, Jie-Li Yu et al. · 0 citations
Open access Aug 2026

Integrated single-cell and spatial transcriptomic analyses identify a unique subset of pro-fibrotic macrophage in kidney fibrosis.

INTRODUCTION Acute kidney injury (AKI) is a severe clinical syndrome associated with high morbidity and mortality, and it possesses high risk of progression to chronic kidney disease (CKD). Renal infiltration of inflammatory cells, particularly macrophages, plays a key role in driving the progression from AKI to CKD....

Liuyan Xiao, Yinyi Long, Xue Hong et al. · 0 citations

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