Author

Yu-Hua Fan

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Jul 2026

STAT6 Targets the Autophagy Pathway to Regulate Microglial Senescence in Cognitive Impairment Caused by Cerebral Small-Vessel Disease

Mechanistically, it was found that phosphorylated STAT6 (pSTAT6) enhanced autophagy, which reduced the burden of senescent microglia and thereby ameliorated CSVD-induced VCI, providing insights into the potential of targeting the STAT6 pathway in VCI associated with CSVD.

Xiaolu Liu, Qing Liu, Jingwen Yang et al. · Neuromolecular medicine · 0 citations

Open access Aug 2026

Interactive Effects of Plasma Alzheimer Disease Biomarkers and White Matter Hyperintensities on Cognitive Decline and Clinical Progression in Nondemented Adults.

It is indicated that phosphorylated tau 217 to β-amyloid 42 ratio and WMHs jointly contribute to clinical progression in nondemented individuals, with astrocytic activation potentially involved in this process.

Jing Yang, Xinyuan Zhao, Yi-Dan Liu et al. · Journal of the American Hear... · 0 citations