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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Yu-Jia Zhou

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Open access Nov 2026

Mechanical Rupture of DNA Tension-Gate Elements: Thresholds, Kinetics, and Energetics from Steered Molecular Dynamics

The kinetics and energetics of load-driven conformational rearrangements underlie DNA replication, repair, and DNA nanodevice function. DNA tension-gate tethers exploit these dynamics, yet their rupture thresholds are set almost exclusively by single-molecule calibration; here, an atomistic steered-molecular-dynamics p...

Yong-Hui Zhang, Yu-Jia Zhou · 0 citations
Open access Oct 2026

Molecular Dynamics Simulations Reveal a Broadly Open Solution Ensemble for the DNA Holliday Junction: Mg2+ Crossover Bridging and Weak Force-Field Sensitivity

Holliday junctions, four-way DNA crossovers central to DNA origami and key intermediates of homologous recombination, must be accurately modeled for rational DNA-nanodevice design, yet their solution conformational ensemble remains incompletely characterized. We characterize this ensemble for the experimental junction...

Yong-Hui Zhang, Yu-Jia Zhou · 0 citations

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