Immune checkpoint inhibitors and adoptive cell therapies have revolutionized cancer treatment, yet their success is accompanied by immune-related hepatotoxicity that can range from asymptomatic enzyme elevation to life-threatening liver failure. Unlike conventional drug-induced liver injury, immune-mediated hepatotoxic...
Yu-Jian Fan, Xiao-Kai Guo, Jiaying Lyu et al.· Medicinal research reviews (...· 0 citations
Drug safety science has expanded beyond patient-level pharmacovigilance to address the environmental consequences of pharmaceutical use. Pharmaceuticals are now detected across diverse ecosystems, but traditional single-compound, high-dose toxicological frameworks remain inadequate for evaluating chronic, low-dose, mul...
Yu-Jian Fan, Xiao-Kai Guo, Jiaying Lyu et al.· Ecotoxicology and Environmen...· 0 citations
An integrated risk assessment framework is proposed that combines adverse outcome pathway analysis, physiologically-based pharmacokinetic modeling, new approach methodologies, and safe-by-design principles to enable predictive hazard identification and supports evidence-based regulation of existing ENMs while enabling...
Yu-Jian Fan, Jiaying Lyu, Xiao-Kai Guo et al.· Journal of materials chemist...· 0 citations
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