UHPLC-HRMS-Based Tissue Pharmacochemistry and Metabolomics Reveal the Effective Components and Potential Mechanism of Huoxue Huayu Gel Plaster Against Oxaliplatin-Induced Peripheral Neuropathy.
Huoxue Huayu Gel Plaster (HXHYGP) is a topical traditional Chinese medicine preparation used for oxaliplatin-induced peripheral neuropathy (OIPN), but its locally exposed bioactive components remain unclear. This study developed an integrated strategy combining pharmacodynamic evaluation, UHPLC-HRMS-based tissue pharma...