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Review Open access Sep 2026

Cancer degronopathies and protein-fate biomarkers in drug resistance and cancer progression: signalling mechanisms, measurement and translational limits

Drug resistance remains a major barrier to durable targeted therapy, and cancer progression often reflects rewiring of signalling pathways that control protein stability. Dysregulation of the ubiquitin–proteasome system, including failure of degron-dependent substrate recognition, can stabilise oncogenic proteins, acce...

Jia-Xin Li, Shu-Han Liu, Lu Fu et al. · 0 citations
Review Open access Aug 2026

OTULIN: a master regulator of linear ubiquitin homeostasis in immune signaling, inflammation, and disease

OTU deubiquitinase with linear linkage specificity (OTULIN) is the only deubiquitinase known to exhibit strict specificity for Met1-linked linear ubiquitin chains, serving as a critical regulator that restrains linear ubiquitin chain assembly complex and maintains inflammatory homeostasis and tissue integrity. Advances...

Ziyu Zhang, Jiahang Lyu, Yujie Bai et al. · 0 citations

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