Structure-Guided Covalent Design and Biological Evaluation of Glycidamido-Leucinamide Antivirulence Agents Against Pseudomonas aeruginosa
Antimicrobial resistance in Pseudomonas aeruginosa has intensified the need for therapies that do not rely solely on bactericidal activity. Antivirulence agents attenuate pathogenic functions and may complement conventional antibiotics. The elastase LasB is a major quorum-sensing (QS)-controlled virulence factor of P....