Matrine induces ferroptosis and suppresses colorectal cancer through targeting the STAT3/SLC7A11 pathway.
Matrine, a natural alkaloid with recognized anti-cancer potential, has been reported to induce cancer cell death. However, the mechanism remains incompletely defined. In this study, we investigated the pharmacological effect of matrine on colorectal cancer (CRC) using both in vivo tumor‑bearing mouse models and in vitr...