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Yu-Long Wen

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Review Open access Sep 2026

Beyond local control: radiotherapy–immunotherapy combinations from in situ vaccination to systemic immune remodeling

Background Radiotherapy (RT) is evolving from local cytotoxicity to systemic immunomodulation. Acting as an in situ vaccine, RT initiates antitumor immunity via immunogenic cell death and cGAS-STING activation. However, RT concurrently triggers counter-regulatory immunosuppression—upregulating PD-L1/TGF-β, expanding Tr...

Yu-Long Wen, Nan-Nan Cheng, Sheng Zhou et al. · 0 citations

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