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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Yulong Zhang

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2 papers indexed here

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Sep 2026

HNRNPK Lactylation Amplifies Inflammation and Exacerbates Myocardial Ischemia/Reperfusion Injury by Regulating Jag2 Splicing.

BACKGROUND Myocardial ischemia/reperfusion injury triggers profound metabolic reprogramming and lactate accumulation. However, how this metabolic stress regulates inflammatory gene expression remains poorly understood. We hypothesized that lactylation, a lactate-derived posttranslational modification, links metabolic s...

Su-Yun Chen, Si-Man Shen, Wen-Mei Su et al. · 0 citations
Open access Jul 2026

Tubular PFKFB3 drives diabetic kidney fibrosis via lactate-dependent H4K12 lactylation and HIPK2 transactivation

Aerobic glycolysis is increasingly recognized as a pathogenic driver in diabetic kidney disease (DKD). However, the epigenetic role of its end product, lactate, remains largely undefined. Spatial transcriptomics analysis revealed active glycolysis in tubular epithelial cells. The participation of histone lactylation in...

Mingkun Xu, Linhang Fu, Yulong Zhang et al. · 0 citations

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