Author

Yu-Lu Gu

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Open access Aug 2026

Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis

Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that plays critical regulatory roles in multiple signaling pathways by preventing the ubiquitin-mediated degradation of its substrates. Dysregulated expression of USP7 is implicated in tumor progression; however, its role in renal fibrosis remains unclear. In the...

Shi-Qi Lv, Zi-Yan Shen, Yu-Lu Gu et al. · Molecular Biomedicine · 0 citations

Open access Sep 2026

Exacerbation of renal interstitial fibrosis by the UHRF1/G9a axis through epigenetic silencing of KLF15

Abstract Renal fibrosis represents a central pathological driver of chronic kidney disease (CKD), yet the epigenetic mechanisms remain incompletely understood. This study identifies a critical role for the Ubiquitin-like with PHD and RING Finger domains 1 (UHRF1)/G9a axis in this process. We demonstrated that both UHRF...

Jia-Yi Wang, Yulin Wang, Shuang-Xin Yuan et al. · Renal Failure · 0 citations