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Author

Yumei Li

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Review Open access Oct 2026

HIF-1α-mediated metabolic reprogramming in hypoxia-driven tumor metastasis

Tumor metastasis is a multistep process that requires profound metabolic plasticity to support cancer cell invasion, survival in circulation, colonization of distant organs, and metastatic outgrowth. Hypoxia is a hallmark of solid tumors and a major driver of metastatic progression. As a central transcriptional regulat...

Shu-Lun Shao, Meng-Xin Wang, Ren-Jian Xie et al. · 0 citations
Aug 2026

MYC-driven BYSL overexpression promotes hepatocellular carcinoma by suppressing nucleolar stress and inactivating the RPL5/RPL11-MDM2-p53 pathway.

It is revealed that BYSL acts as a pivotal downstream mediator of MYC-regulated ribosome biogenesis and promotes hepatocellular carcinoma progression, suggesting that BYSL may represent a potential therapeutic target for hepatocellular carcinoma.

Heyuan Zhao, Hui-Ying Liu, Xia Liu et al. · 0 citations

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