ACSL1 suppresses breast cancer progression by activating ASK1/JNK pathway-mediated autophagy-dependent ferroptosis.
BACKGROUND ACSL1, a critical enzyme involved in fatty acid activation and oxidation, has been associated with several malignancies; however, its specific function in breast cancer remains a subject of debate. OBJECTIVE We sought to identify how ACSL1 operates biologically in breast cancer and to elucidate its modulat...