Aug 2026
Microenvironment-derived APP promotes osteosarcoma malignant phenotypes and induces macrophage M2 polarization via CD74.
The tumor microenvironment plays a critical role in osteosarcoma (OS) progression. However, the mechanisms underlying intercellular communication remain incompletely understood. This study aimed to investigate the role of the APP-CD74 signaling axis in OS and its impact on tumor progression and immune remodeling. Integ...
Chun-Yu Chen, Xue-Lei Zhang, Qiaolian Tao et al.
· Biochimica et biophysica act... · 0 citations