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Open access Oct 2026

TDP-43 Coincides with Noradrenergic Neurons in Alzheimer’s Disease (AD) and Primary Age-Related Tauopathy (PART)

Highlights What are the main findings? TDP-43 mapping across the amygdala, hippocampal subfields, and entorhinal cortex (ERC) reveals preferential accumulation in neuromodulatory noradrenergic neurons. Cell-type colocalization analysis shows limited involvement of glutamatergic terminals and cholinergic neurons, with L...

Gökhan Uruk, Hossam Youssef, Rodolfo Gabriel Gatto et al. · 0 citations
Open access Jul 2026

Diffusion MRI Is More Sensitive Than Tau PET and Regional Volume Loss in Corticobasal Syndrome

White matter microstructural disruption is a dominant imaging signature of CBS and is more closely linked to gray matter volume loss than to measurable uptake on tau PET, while dMRI, particularly MD and ICVF, may provide greatest sensitivity for detecting disease-related changes in CBS.

Yu-Qi Tian, Ryota Satoh, V. Lowe et al. · 0 citations

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