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Yu-Qing Chu

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Review Open access Oct 2026

Synthetic Biology and Systems Metabolic Engineering of Aminoglycoside Antibiotics: From Biosynthetic Pathways to Resistance-Evading and Low-Toxicity Design

Aminoglycoside antibiotics are important therapeutic agents in the clinical treatment of Gram-negative bacterial infections; however, the spread of antimicrobial resistance, together with dose-limiting ototoxicity and nephrotoxicity side effects, substantially restricts their clinical utility. Recent advances in synthe...

Shang-Ye Chu, Yu-Qing Chu, Mo-Han Huang et al. · 0 citations

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