Network toxicology and experimental validation reveal the molecular mechanism of DEHP-induced cochlear hair cell apoptosis and hearing loss.
As a widely utilized plasticizer, di(2-ethylhexyl) phthalate (DEHP) is recognized as a classic environmental endocrine-disrupting chemical. Although DEHP has been implicated in multi-organ toxicity, its ototoxic effects and underlying mechanisms remain poorly understood. This study aimed to investigate DEHP-induced oto...