Open access
Aug 2026
4,4'-dimethoxychalcone induces thermosensitive impairment of SIRT3-associated mitochondrial signaling and apoptotic cell death with therapeutic potential in cancer.
DMC is identified as a thermosensitive inhibitor of SIRT3 and mechanistic insights into its potential to disrupt mitochondrial homeostasis for targeted cancer therapy are provided.
Yu Song, Qing-Li Zhao, Ryohei Ogawa et al.
· Chemico-Biological Interacti... · 0 citations