Review
Open access
Sep 2026
Orchestrating Stress Granule Dynamics by SUMOylation: A New Frontier in Treating Stress-Induced Age-Related Diseases.
Stress granules (SGs), membrane-less organelles formed via liquid-liquid phase separation (LLPS), function as essential adaptive compartments that sequester mRNAs and proteins during acute stress. However, during chronic stress or aging, these dynamic condensates can undergo an irreversible phase transition into pathol...
Jia-Cheng Zhang, Han Hu, Yu-Tian Zhu et al.
· Pharmacological Research · 0 citations