Author

Yu-Wei Chang

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Open access Sep 2026

Subset-guided IL-15 expansion of NK cells amplifies antigen-specific CD4+ T cell immunity in melanoma

Natural killer (NK) cells comprise heterogeneous subsets with distinct developmental trajectories and effector functions; however, whether specific NK subsets can selectively coordinate adaptive antitumor immunity remains unclear. We identified a bone marrow-derived CD11c + B220 + NK subset (DPNKs) that is...

Chu-Yun Shen, Yu-Wei Chang, Li-Wen Tseng et al. · Cancer Immunology and Immuno... · 0 citations

Open access Jul 2026

Human umbilical cord-derived mesenchymal stem cells ameliorate muscle dysfunction and metabolic dysregulation in the CuZnSOD null mouse model of sarcopenia.

These findings demonstrate that UC-MSCs function as context-dependent metabolic modulators, alleviating oxidative stress-induced sarcopenia through attenuation of oxidative stress, restoration of systemic IGF-1, and selective reprogramming of lipid metabolism, while dynamically adjusting energy metabolism in physiologi...

Gilbert Aaron Lee, Li-Wen Tseng, Yu-Wei Chang et al. · Experimental Gerontology · 0 citations