Review
Open access
Sep 2026
Engineering TnpB as a compact RNA-guided genome editor from molecular constraints to design principles
Recent discoveries of non-CRISPR RNA-guided nucleases have expanded the landscape of programmable genome editing beyond canonical Cas systems. Among these, TnpB proteins derived from IS200/IS605-family transposable elements are ultra-compact RNA-guided DNA endonucleases with potential for delivery-constrained genome en...
Bin Ma, Yi-Miao Li, Dong-Sheng Zhang et al.
· Frontiers in Genome Editing · 0 citations