Review
Open access
Nov 2026
Integrating noncanonical amino acids and synthetic cofactors for the development of artificial metalloenzymes
Natural metalloenzymes harness the sophisticated synergy between canonical amino acids and metal cofactors to catalyze life-sustaining reactions. However, the limited chemical diversity of the twenty standard amino acids often restricts non-natural transformations. To overcome these constraints, artificial metalloenzym...
Si-Meng Ding, Yu-Xin Shi, Ren-Jun Gao et al.
· Communications Chemistry · 0 citations