Multi-reward policy optimization requires a joint update that reflects both the learning signals and the intended relationships among objectives. We introduce Objective-wise Reconciled Policy Gradient (ORPG), which constructs a separate clipped policy objective for each reward and reconciles the resulting gradients int...
Shi-Cheng Fang, Yi-Wen Zhao, Wen-Bo Tian et al.· 0 citations
ABOPD is introduced, an antibody design framework based on on-policy distillation that leverages privileged native geometry during training to supervise states visited along the model's own denoising trajectories, offering a path to higher-fidelity protein design.
A paired ablation that removes explicit scientific guidance while preserving the repository and executable engineering context shows that scientific knowledge is not uniformly beneficial: well-grounded information can constrain repair and improve average performance and token efficiency, whereas poorly aligned guidance...
Zhi-Peng Xu, Jia-Hao Lu, Yi-Ning Zheng et al.· 3 citations
AgentHPOBench, a sequential benchmark comprising 30 executable machine learning tasks across seven research categories, shows that current agents exhibit measurable experimental optimization ability across domains, but still face clear limitations in sustained iterative refinement, complex log diagnosis, and consistent...
Applications in materials analysis, molecule design, and protein or antibody screening, together with experiments on scientific reading, idea generation, molecule generation, and antibody screening, show that SCION outperforms existing autonomous research-agent baselines, especially in decomposition, verification, refi...
Y. Zheng, Yuxin Wang, Jiahao Lu et al.· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.