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Yuxue Wang

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Open access Sep 2026

GWAS-by-Subtraction Resolves Coronary Artery Disease-Related and Model-Defined Residual Genetic Components of Ischaemic Stroke

Background/Objectives: Genetic overlap between any ischaemic stroke (AIS) and coronary artery disease (CAD) can obscure associations less closely tied to coronary risk. We aimed to separate coronary-shared from residual AIS genetic effects. Methods: We applied GWAS-by-subtraction to GIGASTROKE AIS and UK Biobank/CARDIo...

Bin-Yang Wang, Yu-Xue Wang, Yong Yin · 0 citations
Review Open access Jul 2026

Molecular Mechanisms of Targeted Therapy in Breast Cancer: An Integrated Signaling Network Perspective.

This work synthesizes current evidence on the signaling architecture underlying targeted therapy across breast cancer subtypes and proposes a four-layer network topology model of resistance integrating receptor tyrosine kinase reprogramming, epigenetic plasticity coupled with tumor microenvironment (TME) co-evolution,...

Yadong Wang, Maona Zhang, Xuefang Zhang et al. · 1 citation

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