Author

Yu-Yan Cheng

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Open access Oct 2026

X-SPEAR: An Extensible Framework for Spatial Panel Evaluation and Refinement

Targeted spatial transcriptomics platforms such as 10x Genomics Xenium measure a predefined panel of genes. A gene is usually detected in fewer cells in the spatial assay than in the single-cell RNA sequencing (scRNA-seq) reference used to choose it, by an amount that differs from gene to gene. We present eXtensible Sp...

Rushil Patel, Bryant Duong, Veer Patel et al. · bioRxiv · 0 citations

Review Open access Aug 2026

Experimental models to study oxidative stress in glaucoma: integrating in vitro, in vivo, and clinical studies

Glaucoma is a complex optic neuropathy and the leading cause of permanent blindness worldwide. Elevated intraocular pressure (IOP) is the major modifiable risk factor for this disease. Growing evidence suggests that oxidative stress and reactive oxygen species (ROS) are key mediators of retinal ganglion cell (RGC) deat...

Laxmi Moksha, Yan Zhu, R. Salowe et al. · Frontiers in Pharmacology · 0 citations