Author

Yu-Yan Zhou

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Open access Sep 2026

Securidaca inappendiculata Extract Mitigates Joint Damage in Collagen‐Induced Arthritis Rats Through Modulation of the SIRT1/HIF‐1α/Glycolysis Pathway

ABSTRACT Securidaca inappendiculata (SI) Hassk. is a traditional Chinese herbal medicine commonly used in Southern China for the treatment of rheumatoid arthritis (RA). However, its exact mechanism of action remains unclear. In this study, we evaluated the therapeutic effects of the SI‐derived compound 1,7‐dihydroxy‐3,...

Yu-Yan Zhou, Yu-Yun Zhou, Ruo-Xuan Xiang et al. · Pharmacology Research & Pers... · 0 citations

Aug 2026

Network Pharmacology and Experimental Validation of a Securidaca inappendiculata Xanthone Fraction Targeting Rheumatoid Arthritis via the PI3K/AKT/mTOR/HIF-1α/GSK-3β Axis.

This work elucidated the anti-RA mechanism of S. inappendiculata: eight xanthones acted on the PI3K/AKT/mTOR/HIF-1α/GSK-3β axis to induce M1 macrophage apoptosis, validating the integrated approach and laying groundwork for RA treatment and natural product research.

Xuan Chen, Bing-Ru Fan, Ting Wang et al. · Current Computer - Aided Dru... · 0 citations