Yu-Ying Wang

Design, synthesis and biological evaluation of novel aminopyrimidine derivatives as potent EGFRC797S inhibitors for overcoming osimertinib resistance.

EGFRC797S mutation and bypass pathway activation are major drivers of acquired resistance to osimertinib; however, no approved therapeutic agents are currently available to effectively overcome this resistance. In this study, a series of aminopyrimidine-based small-molecule inhibitors were rationally designed and synth...