Yu Zhang

Radical Markovnikov Hydroboration of Unactivated Terminal Alkenes With HBaza-Type Hydroborane via a Triple Catalysis.

Organoboron compounds are versatile building blocks for C─C and C-heteroatom bond formation, with broad applications in drug discovery and materials science. Hydroboration of alkenes with hydroboranes is a reliable route to access organoboron compoundsssssss, yet the Markovnikov-selective hydroboration of unactivated t...

Designing enzymes for new-to-nature chemistry and non-natural substrates with AlphaProtein Novo

Design-Evolution Synergy Enables New-to-Nature Enzyme Chemistry

It is demonstrated de novo enzyme design can enable challenging, high-energy-barrier enzyme chemistry with programmable regio- and enantioselectivity, high catalytic efficiency, excellent enzyme stability, and scaffold diversity.