Author

Yu Zhang

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Sep 2026

Spatiotemporally controlled degradation of CDK6 via light-triggered ROS generation: uncovering the proximity effect-mediated dual target depletion.

Cyclin-dependent kinase 6 (CDK6) is a key therapeutic target in breast cancer, and its abnormal activation, together with Cyclin D3, promotes uncontrolled cell proliferation. Traditional CDK4/6 inhibitors only inhibit kinase activity without degrading the target protein, which readily causes drug resistance. In this st...

Wei Zhang, Long-Li Hu, Yang-Jiong He et al. · Organic and biomolecular che... · 0 citations

Aug 2026

Novel Piperlongumine derivatives exert multimodal antitumor effects in prostate cancer via MAPK pathway activation, poly-mechanistic apoptosis induction, and DNMT3A-mediated DNA methylation reduction.

In vivo validation in PC-3 xenograft mice confirmed that 11 M exerted robust tumor growth suppression with low systemic toxicity, accompanied by DNMT3A downregulation and MAPK pathway activation, substantiating its multi-target therapeutic mechanism.

Yu Zhang, Xue Yang, Xuemei Qiu et al. · Bioorganic chemistry (Print) · 0 citations