Open access
Aug 2026
Activation of the Nrf2-ARE Signaling Pathway Mediates the Neuroprotective Effects of Exercise in a Mouse Model of Chronic Parkinson’s Disease
Clear pharmacological evidence is provided that the neuroprotective effect of regular treadmill exercise against chronic PD strictly depends on the Nrf2-ARE pathway, indicating that Nrf2 is a key mechanistic node linking exercise and neuroprotection.
Shu-Wei Zhang, Dong Yang, Chang-Fa Tang et al.
· International Journal of Mol... · 0 citations