Synthesis of 2-Methylquinazolinones Through Skeleton Editing Strategy Using Calcium Carbide as an Inorganic C2 Source.
A skeleton editing strategy for the construction of 2-methylquinazolin-4(3H)-ones is described. This transformation employs commercially available benzo[c]isoxazoles as the skeleton framework, calcium carbide as an inorganic C2 source, and sulfonyl azides as nitrogen sources. The reaction proceeds via a cascade of [3 +...