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Author

Yu Zheng

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Review Open access Oct 2026

Immune cell metabolic reprogramming in pancreatic cancer: roles in tumor progression and therapeutic strategies

Pancreatic cancer is one of the most lethal malignancies of the digestive system, and its profoundly immunosuppressive tumor microenvironment (TME) represents a major driver of tumor progression and therapeutic resistance. Emerging evidence indicates that metabolic reprogramming profoundly influences the polarization,...

Gang-Zhao Gu, Yang Du, Heng-Zhi Zhang et al. · 0 citations
Open access Jul 2026

Single-cell RNA-seq and spatial transcriptomics characterize CD8+ exhausted T cells in pancreatic ductal adenocarcinoma

Low SPP1 and PLAUR expression correlated with poor prognosis in TCGA-PAAD and two key LR pairs mediated crosstalk between cancer cells and CD8+ Tex cells, confirmed by immunofluorescence, spatial mapping, and protein docking.

Jing Mao, Chenxin Yan, Ying Mei et al. · 0 citations

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