Epigenetic dysregulation in Clear cell renal cell carcinoma: from mechanisms to precision medicine.
Clear cell renal cell carcinoma (ccRCC) is a paradigm of epigenetic dysregulation. The characteristic loss of chromosome 3p leads to the inactivation of a constellation of pivotal epigenetic regulators, including PBRM1, SETD2, and BAP1, reshaping the epigenome across multiple layers. This review synthesizes the major e...