Yuan-Qing Li

Targeting Cys328 in the STAT3 DNA-binding domain with the germacrane-type sesquiterpene lactone SCP-7 inhibits colorectal Cancer growth in vitro and in vivo.

Signal transducer and activator of transcription 3 (STAT3) is a critical oncogenic driver hyperactivated in approximately 70% of human cancers, especially colorectal cancer (CRC), making it an attractive therapeutic target. Currently, the discovery of STAT3 inhibitors is primarily focused on the SH2 domain, however, th...