Y. Chen

Hierarchical Phase Transitions in Bayesian Flow Networks Enable Training-Free Molecular Design

Bayesian flow networks (BFNs) jointly model atomic coordinates and atom types for structure-based drug design, but their generative dynamics remain poorly understood. We show that the two channels resolve on different terms: atom types pass through a sharp commitment transition at tc1, whereas coordinate precision im...

[Optical genome mapping analysis of a Chinese pedigree with a complex balanced translocation involving four chromosomes].

Biallelic variants in IBA57 with multiple mitochondrial dysfunction syndrome 3

The compound heterozygous IBA57 mutations c.310G>T and c.826C>T lead to reduced IBA57 protein expression, selective impairment of respiratory chain complex II, and transcriptional dysregulation of the PI3K-Akt pathway, together contributing to the MMDS3 phenotype in the proband and the affected fetus.