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Author

Yuan Sui

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2 papers indexed here

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Open access Oct 2026

PRMT5 promotes ferroptosis in cisplatin-induced acute kidney injury through WDR5/ACSL4 pathway.

The epigenetic mechanisms driving the transition to ferroptosis in acute kidney injury (AKI) remain unclear. In this study, protein methyltransferase 5 (PRMT5) and its partner MEP50 were significantly upregulated in the renal tubules of AKI patients and murine models. Genetic silencing of PRMT5 via AAV-shRNA in vivo an...

Jia-Wen Lin, Jun-Xuan Fang, Tian-Jiao Cui et al. · 0 citations
Sep 2026

Abstract A061: Spatial Whole-Transcriptome Profiling Reveals Immune-Suppressive Stromal Niches and Associated Ductal Tumor Cell-State Programs in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked spatial heterogeneity and a highly variable immune microenvironment, ranging from myeloid-enriched, immune-suppressive regions to more immune-responsive niches. How tumor epithelial and stromal compartments contribute to these spatial immune states, a...

Yuan Sui, Jonathan R. Weitz, Jessica Bruning et al. · 0 citations

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