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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Yuan-Yuan Qiao

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Open access Sep 2026

Syndecan-4 drives immune escape in microsatellite-stable colorectal cancer by suppressing the formation of cytotoxic effector T cells via the PRKCA–TNFα–NF-κB axis

Approximately 85% of colorectal cancers (CRCs) are mismatch repair proficient/microsatellite stable (pMMR/MSS), a subtype that is resistant to immunotherapy because of its immunosuppressive tumor microenvironment (TME). However, the molecular determinants underlying immune evasion in MSS-type CRC remain incompletel...

Shun-Yi Wang, Yuehong Chen, Sheng-Zhi Ye et al. · 0 citations

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