Chemogenetic Manipulation of mPFC Neurons Counteracts Cognitive Deficits But Leaves Sleep Disturbances Unaffected in a Mouse Model of Chronic Intermittent Hypoxia
The mPFC is a critical hub for CIH-induced cognitive impairment, and its targeted inhibition can restore cognitive and synaptic function, however, sleep architecture disruptions are governed by distinct mechanisms, indicating a dissociation between CIH-mediated cognitive and sleep pathologies.