Author

Yuanyuan Zhang

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Open access Sep 2026

Multi-omics mapping of PSC genetic risk to a high TWAS-active JAML+ lipid-associated macrophage program: bridging single-cell heterogeneity, spatial fibrotic niches, and machine learning selection

Background Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with progressive peribiliary inflammation and fibrosis. Disease-modifying therapies are lacking, and the cell-type-specific mechanisms linking genetic susceptibility to pathogenic immune states remain incompletely understood. Methods...

Zhong-Yan Du, Zhi-Hao Xu, Chen-Xiao Yang et al. · Frontiers in Cell and Develo... · 0 citations

Review Open access Jul 2026

Probiotics, Gut Microbiome, and Livestock Production: From Mechanisms of Action to Precision Breeding

This review systematically summarizes the core mechanisms by which probiotics modulate meat quality, feed efficiency and small intestinal and cecal health in pigs and broilers via the gut–muscle axis, nutrient metabolic axis, and immune regulatory axis and elucidates the heritable effects of host genetics on shaping th...

Jia Tian, Li'e Hou, Yuan-Yuan Zhang et al. · Fermentation · 0 citations